Ubiquitin D

Identifiers

UBD; FAT10; GABBR1; UBD-3

External IDs

OMIM: 606050 MGI: 1344410 HomoloGene: 4665 GeneCards: UBD Gene

Gene Ontology
Molecular function	• protein binding • proteasome binding
Cellular component	• nucleus • cytoplasm • aggresome
Biological process	• proteolysis • ubiquitin-dependent protein catabolic process • protein ubiquitination • protein modification by small protein conjugation • response to interferon-gamma • response to tumor necrosis factor • negative regulation of mitotic prometaphase • myeloid dendritic cell differentiation • positive regulation of apoptosis • positive regulation of I-kappaB kinase/NF-kappaB cascade • aggresome assembly
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr c6_COX:
29.67 – 29.67 Mb

Chr 17:
37.33 – 37.33 Mb

PubMed search

[1]

[2]

Ubiquitin D is a protein that in humans is encoded by the UBD gene.^[1]^[2]^[3]

Interactions

UBD (gene) has been shown to interact with NUB1^[4] and MAD2L1.^[5]

References

^ Bates EE, Ravel O, Dieu MC, Ho S, Guret C, Bridon JM, Ait-Yahia S, Briere F, Caux C, Banchereau J, Lebecque S (Dec 1997). "Identification and analysis of a novel member of the ubiquitin family expressed in dendritic cells and mature B cells". Eur J Immunol 27 (10): 2471–7. doi:10.1002/eji.1830271002. PMID 9368598.
^ Fan W, Cai W, Parimoo S, Schwarz DC, Lennon GG, Weissman SM (Aug 1996). "Identification of seven new human MHC class I region genes around the HLA-F locus". Immunogenetics 44 (2): 97–103. doi:10.1007/BF02660056. PMID 8662070.
^ "Entrez Gene: UBD ubiquitin D". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10537.
^ Hipp, Mark Steffen; Raasi Shahri, Groettrup Marcus, Schmidtke Gunter (Apr. 2004). "NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation". J. Biol. Chem. (United States) 279 (16): 16503–10. doi:10.1074/jbc.M310114200. ISSN 0021-9258. PMID 14757770.
^ Liu, Y C; Pan J, Zhang C, Fan W, Collinge M, Bender J R, Weissman S M (Apr. 1999). "A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (8): 4313–8. doi:10.1073/pnas.96.8.4313. ISSN 0027-8424. PMC 16329. PMID 10200259. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16329.

Mazzé FM, Degrève L (2006). "The role of viral and cellular proteins in the budding of human immunodeficiency virus.". Acta Virol. 50 (2): 75–85. PMID 16808324.
Ott DE, Coren LV, Copeland TD, et al. (1998). "Ubiquitin is covalently attached to the p6Gag proteins of human immunodeficiency virus type 1 and simian immunodeficiency virus and to the p12Gag protein of Moloney murine leukemia virus.". J. Virol. 72 (4): 2962–8. PMC 109742. PMID 9525617. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109742.
Liu YC, Pan J, Zhang C, et al. (1999). "A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2.". Proc. Natl. Acad. Sci. U.S.A. 96 (8): 4313–8. doi:10.1073/pnas.96.8.4313. PMC 16329. PMID 10200259. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16329.
Schubert U, Ott DE, Chertova EN, et al. (2001). "Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2.". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13057–62. doi:10.1073/pnas.97.24.13057. PMC 27177. PMID 11087859. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=27177.
Strack B, Calistri A, Accola MA, et al. (2001). "A role for ubiquitin ligase recruitment in retrovirus release.". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13063–8. doi:10.1073/pnas.97.24.13063. PMC 27178. PMID 11087860. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=27178.
Ott DE, Coren LV, Chertova EN, et al. (2001). "Ubiquitination of HIV-1 and MuLV Gag.". Virology 278 (1): 111–21. doi:10.1006/viro.2000.0648. PMID 11112487.
Strack B, Calistri A, Göttlinger HG (2002). "Late assembly domain function can exhibit context dependence and involves ubiquitin residues implicated in endocytosis.". J. Virol. 76 (11): 5472–9. doi:10.1128/JVI.76.11.5472-5479.2002. PMC 137019. PMID 11991975. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137019.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ott DE, Coren LV, Sowder RC, et al. (2003). "Retroviruses have differing requirements for proteasome function in the budding process.". J. Virol. 77 (6): 3384–93. doi:10.1128/JVI.77.6.3384-3393.2003. PMC 149504. PMID 12610113. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=149504.
Lee CG, Ren J, Cheong IS, et al. (2003). "Expression of the FAT10 gene is highly upregulated in hepatocellular carcinoma and other gastrointestinal and gynecological cancers.". Oncogene 22 (17): 2592–603. doi:10.1038/sj.onc.1206337. PMID 12730673.
Brès V, Kiernan RE, Linares LK, et al. (2003). "A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter.". Nat. Cell Biol. 5 (8): 754–61. doi:10.1038/ncb1023. PMID 12883554.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Hipp MS, Raasi S, Groettrup M, Schmidtke G (2004). "NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation.". J. Biol. Chem. 279 (16): 16503–10. doi:10.1074/jbc.M310114200. PMID 14757770.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Hipp MS, Kalveram B, Raasi S, et al. (2005). "FAT10, a ubiquitin-independent signal for proteasomal degradation.". Mol. Cell. Biol. 25 (9): 3483–91. doi:10.1128/MCB.25.9.3483-3491.2005. PMC 1084302. PMID 15831455. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1084302.
Gottwein E, Kräusslich HG (2005). "Analysis of human immunodeficiency virus type 1 Gag ubiquitination.". J. Virol. 79 (14): 9134–44. doi:10.1128/JVI.79.14.9134-9144.2005. PMC 1168789. PMID 15994808. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1168789.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Ubiquitin D

Interactions

References

Further reading